ABSTRACT
About seven months after the start of the COVID-19 pandemic, the first vaccine against the disease was approved for emergency use. Since then, twenty-three more vaccines have been approved, while more than three hundred are in development. Despite being one of the fastest vaccines ever created, several questions about it remain open. Computational models can be useful to answer some of these questions. This paper aims to evaluate whether a computer model previously used to reproduce the effects of the yellow fever vaccine in the body is also capable of reproducing the effects of a distinct vaccine: ChAdOx1 nCoV-19. Preliminary results show that the model is a promising tool to achieve this goal since it was able to reproduce the antibody curves observed in individuals vaccinated with ChAdOx1 nCoV-19. © 2021 IEEE.
ABSTRACT
By November 2020, the Coronavirus disease 2019 (COVID-19) has infected more than 50 million people worldwide, causing more than 1.2 million deaths. This new contagious disease is not well understood, and the scientific community is trying to comprehend better the interactions of the causative agent of the disease, SAR2-CoV-2, and the immune response to identify its weak points to develop new therapies to impair its lethal effects. Mathematical and computational tools can help in this task: the multiscale interactions among the various components of the human immune system and the pathogen are very complex. In this work, we present a simple system of five ordinary differential equations that can be used to model the immune response to SARS-CoV-2. The model parameters and initial conditions were adjusted to cohort studies that collected viremia and antibody data. The results have shown that the model was able to reproduce both viremia and antibodies dynamics successfully. © 2020 IEEE.
ABSTRACT
This essay consists of eight letters exchanged between the authors over the course of April 2020, on the topic of online analysis. Resuming the methodological approach of theoretical production via correspondence, widely used by Freud and his interlocutors, the article weaves concepts-events regarding psychological care mediated by information and communication technologies, as well as shifts in the status of clinical listening, which reverberate especially on the unconscious, the presence of the analyst and issue of recording. The epistolary writing enabled an affectionate and deinstitutionalized elaboration, breaking with academic logic, without losing the conceptual rigor of the Freudian-Lacanian field in dialogue with other authors. The discussions presented reflect on which lives can be heard in analysis, online or otherwise, in varying unfoldings that circumscribe a contemporary clinic. © 2022. Psicologia USP. All Rights Reserved.